Protein aggregation drives cell aging in a size-specific manner in
Abstract
Aging, the decline in physiological function over time, is marked by the intracellular accumulation of damaged components. It can be attributed to trade-offs between organismal maintenance and the generation of high-quality offspring, where the parent retains damage upon reproduction and produces rejuvenated descendants. This occurs even in bacteria, such as
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Research summary
Protein aggregation drives cell aging in a size-specific manner. The paper addresses the mechanisms of aging at a cellular level, focusing on protein aggregation as a contributing factor, which is directly related to understanding and potentially mitigating the root causes of aging.
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