Temporal transcriptomic profiling reveals distinct age-associated gene expression signatures in gonads under reduced insulin/IGF-1 signaling in Caenorhabditis elegans.

Neha Kaushik, Soumya Rastogi, Shivani Kapadia, Vaibhav Jain, Sonia Verma, Deepak Pandey, Mona Sharma, Surabhi Gupta, Ashutosh Halder, Simon Gregory, Neeraj Kumar

Department of Reproductive Biology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.Department of Reproductive Biology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. · pubmed

Paper

Abstract

Age-related decline in reproductive function is a hallmark of organismal aging, yet the molecular mechanisms driving this process remain incompletely understood. The insulin/IGF-1 signaling (IIS) pathway is highly conserved and influences both lifespan and reproductive aging in Caenorhabditis elegans, where reduced IIS extends reproductive span. While prior studies have examined isolated tissues or time points, a comprehensive temporal analysis of gonadal transcriptional dynamics under reduced IIS has been lacking. Here, we compared IIS-dependent regulation of the gonadal transcriptome with that of other somatic tissues to uncover tissue-specific mechanisms of reproductive aging.

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Research summary

The paper claims that distinct age-associated gene expression signatures in gonads are regulated by reduced insulin/IGF-1 signaling in C. elegans. This research is relevant as it explores the molecular mechanisms of reproductive aging, which is a critical aspect of organismal aging and longevity.

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