Aging-associated transcriptional programs in T cells signify constituents of TGF-β signaling for immunosenescence.

Renke He, Chanchan Xiao, Wen Lei, Guobing Chen, Yangqiu Li, Oscar Junhong Luo

Department of Hematology, First Affiliated Hospital, School of Medicine, Jinan University, Guangzhou, China.Department of Hematology, First Affiliated Hospital, School of Medicine, Jinan University, Guangzhou, China. · pubmed

Paper

Abstract

Immunosenescence, particularly the altered ratio of naïve and memory T cells, contributes to a diminished immune reserve and impaired adaptive immunity in aging and frail populations. The role of TGF-β signaling pathway-a critical hallmark of organismal senescence and T-cell exhaustion-in terminally differentiated effector memory T (Temra) cells remains elusive. We devised single-cell and bulk-cell RNA sequencing (RNA-seq) datasets to identify age-group-specific transcriptional regulatory networks in T cells and elucidate the roles of TGF-β signaling constituents associated with immunosenescence in Temra.

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Research summary

The paper identifies age-group-specific transcriptional regulatory networks in T cells and elucidates the roles of TGF-β signaling in immunosenescence. This research is relevant as it addresses the mechanisms of immunosenescence, which is a key aspect of aging and could contribute to understanding and potentially mitigating age-related immune decline.

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