Strength but not power training increases soluble alpha klotho levels in pre-frail older adults.

Michaela Rippl, Martin Bidlingmaier, Linda Deissler, Sebastian Martini, Katharina Mueller, Sabine Schluessel, Ralf Schmidmaier, Júnia R O L Schweizer, Olivia Tausendfreund, Laura Welscher, Michael Drey

LMU Munich Hospital, Department of Medicine IV, Geriatrics, Ziemssenstr. 5, 80336, Munich, Germany. Electronic address: [email protected] Munich Hospital, Department of Medicine IV, Geriatrics, Ziemssenstr. 5, 80336, Munich, Germany. Electronic address: [email protected]. · pubmed

Paper

Abstract

Loss of physical function is a growing health concern in aging populations. Resistance training, including strength training (ST) and power training (PT), is the main therapeutic approach, yet evidence regarding the most effective modality remains inconsistent. Soluble alpha klotho (sαKL) is a protein increasingly recognized for its role in muscle function and may serve as a biomarker of training responsiveness due to its association with aging, muscle integrity, and exercise-induced adaptions. Therefore, we aimed to investigate whether ST and PT differentially influence sαKL levels in older adults.

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Research summary

Strength training increases soluble alpha klotho levels in pre-frail older adults. The study addresses the role of soluble alpha klotho in muscle function and its potential implications for aging, which aligns with the goal of understanding and improving health in older populations.

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