Long-term high-protein diet intake accelerates adipocyte senescence through macrophage CD38-mediated NAD

Xiaohan Yang, Lun Hua, Dengfeng Gao, Yanni Wu, Yi Yang, Xianyang Jin, Xuemei Jiang, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Long Jin, Yong Zhuo, Mingzhou Li, De Wu

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, 611130, China; Animal Nutrition and Efficient Feed Utilization Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China. · pubmed

Paper

Abstract

High-protein (HP) diets are widely adopted in Western societies for body-weight management; yet, they exacerbate senescence-associated metabolic deterioration, posing an unresolved pathophysiological conundrum. Here, we demonstrate that long-term HP intake mediates adipocyte-specific NAD

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Research summary

Long-term high-protein diet intake accelerates adipocyte senescence through macrophage CD38-mediated NAD. The paper addresses the impact of dietary choices on cellular aging processes, which is directly related to the mechanisms of aging and longevity.

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