Subcellular In Vivo Cardiac Proteomics Reveals Sarcomere and Ribosome Interactomes and skNAC's Impact on Cardiac Proteostasis.

Rami Haddad, Omer Sadeh, Tamar Ziv, Nardeen Shehdeh, Nadav Keren, Izhak Kehat

The Rappaport Institute and the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa. (R.H., O.S., N.S., N.K., I.K.). · pubmed

Paper

Abstract

Proteostasis and the regulation of protein folding and sorting play a critical role in maintaining cellular homeostasis. The failure of proteostasis contributes to heart failure and aging, but, despite its importance, the mechanisms and factors regulating proteostasis in cardiomyocytes remain poorly characterized.

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Research summary

The paper claims to identify the interactomes of sarcomeres and ribosomes in cardiomyocytes and the role of skNAC in cardiac proteostasis. The study addresses the mechanisms of proteostasis in cardiomyocytes, which is crucial for understanding heart failure and aging, thus contributing to the broader field of longevity research.

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