Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis.

Yuhe Jiang, Jianqi She, Zeying Wang, Yuan Zhu, Yunsong Liu, Ping Zhang, Hao Liu, Xiao Zhang, Yongsheng Zhou

Department of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.Department of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China. · pubmed

Paper

Abstract

Senile bone-fat imbalance poses a significant public health burden in aging populations. This study investigates how aging affects the heterogeneity of mesenchymal stem cell (MSC)-derived apoptotic vesicles (apoVs) and develops a therapeutic strategy to rectify age-related bone-fat metabolic disorders.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that apoptotic vesicles can rectify age-related bone-fat metabolic disorders by activating the Thy1-ERK-TAZ axis. This research addresses a specific aspect of aging-related metabolic imbalance, which is relevant to understanding and potentially mitigating the effects of aging on bone and fat tissue.

Author of this paper? Send a correction.