Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) - possible combination use.

Savani Ulpathakumbura, Sicong Kenric Lu, Rasika Gunarathne, John Zhiyong Yang, Johnson Liu, Xiaodong Jin, Qiang Zhou, Jun Lu

Auckland Bioengineering Institute, University of Auckland, Auckland 1142, New Zealand; National Institute of Fundamental Studies, Hantana Road, Kandy 20000, Sri Lanka.Auckland Bioengineering Institute, University of Auckland, Auckland 1142, New Zealand; National Institute of Fundamental Studies, Hantana Road, Kandy 20000, Sri Lanka. · pubmed

Paper

Abstract

Aging is a complex biological process characterized by the gradual deterioration of cellular functions, leading to an increased susceptibility to chronic diseases. In the search for interventions to promote healthy aging and extend lifespan, Pyrroloquinoline Quinone (PQQ) and Nicotinamide Mononucleotide/Nicotinamide Riboside (NMN/NR) have emerged as promising anti-aging agents. PQQ exerts its anti-aging effect primarily through enhancing mitochondrial biogenesis, exerting antioxidant activity, and modulating inflammatory pathways. On the other hand, NMN/NR act as key precursors in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in energy metabolism, cellular homeostasis, and DNA repair, thereby promoting longevity. This review systematically compares the mechanisms of action and efficacy of those compounds in mitigating age-related complications. Furthermore, this emphasizes the potent synergistic effect when PQQ and NMN/NR are used in combined formulations, highlighting their complementary pathways to support healthy aging. Despite supporting preliminary data and patented formulations, strong scientific evidence encouraging the synergistic anti-aging potential of PQQ and NMN/NR remains limited, highlighting the need for robust studies. Collectively, PQQ and NMN/NR offer distinct complementary strategies to promote healthy aging and prevent age-related diseases; their combination could offer a more effective approach to enhance healthy aging and longevity.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that the combination of PQQ and NMN/NR may enhance healthy aging and longevity through their complementary mechanisms. The focus on potential interventions that target the biological processes of aging aligns with longevity research.

Author of this paper? Send a correction.