Integration of multiple omics reveals key targets and cellular mechanisms for intervention in sarcopenia.

Zhu Zhu, Wenji Wang, Qi Zhang, Xiao Bi, Shaojun Ma, Yue Shen, Feng Ding

Department of geriatrics, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.Department of geriatrics, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. · pubmed

Paper

Abstract

Sarcopenia, an age-related syndrome characterized by progressive loss of muscle mass, strength, and function, presents a significant global health burden with limited therapeutic interventions. This study integrates genomic causality, multi-tissue omics, and cellular mediation analyses to identify and prioritize mechanistically grounded therapeutic targets.

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Research summary

This study identifies and prioritizes therapeutic targets for sarcopenia through multi-omics integration. The research addresses a significant age-related condition and aims to uncover mechanisms that could lead to interventions, aligning with the goals of longevity research.

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