Network pharmacology-based cocktail of four Ginkgo biloba compounds enhances yeast mitochondrial function and longevity.

Yi Ding, Jingjing Li, Junlin Li, Dengke Chen, Feifan Yu, Zhiyi Liu, Yu Zhang, Yali Dai, Yating Huang, Jinye Dang

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China.Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China. · pubmed

Paper

Abstract

Cellular aging is characterized by oxidative stress and mitochondrial dysfunction. Pharmacological inhibition of cellular aging holds significant promise. Ginkgo biloba extract (GBE), a crude extract rich in bioactive natural products, has shown potential in mitigating age-related pathologies pharmacologically, However, its anti-aging effects, active components, and underlying mechanisms remain unclear.

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Research summary

The paper claims that a cocktail of four Ginkgo biloba compounds enhances yeast mitochondrial function and longevity. This research addresses the root causes of aging by exploring the potential of natural compounds to improve mitochondrial function, which is a key factor in cellular aging.

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