The nonlinear U-shaped association between vitamin D deficiency and biological aging acceleration is enhanced in individuals with higher inflammation levels.

Jatupol Kositsawat, George A Kuchel, Kelin Zhong, Shangshu Zhao, Richard H Fortinsky, Chia-Ling Kuo

Center on Aging, University of Connecticut, Farmington, CT. · pubmed

Abstract

Aging is multifactorial, yet aging research emphasizes independent risk factors. Endocrine and inflammatory factors have been linked to opposing and synergistic associations with suboptimal aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that vitamin D deficiency has a nonlinear U-shaped association with biological aging acceleration, particularly in individuals with higher inflammation levels. This research is relevant as it explores the interplay between vitamin D, inflammation, and biological aging, potentially addressing root causes of aging rather than merely treating symptoms.

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