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RESEARCH PAPER / 2025-12-12

Social isolation and intrinsic capacity decline in older adults: Mediating roles of sleep duration and pain.

Wenhua Yu, Yaru Zhou, Xvyan Gao, Jiayu Han, Li Zhang, Lina Ma

Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, 100053, Beijing, China.Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, 100053, Beijing, China. · pubmed

Abstract

The decline of intrinsic capacity is a key determinant of healthy aging. While social isolation is recognized as a risk factor for functional deterioration in older adults, the pathways through which it influences intrinsic capacity, particularly via sleep duration and pain, remain underexplored.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Social isolation negatively impacts intrinsic capacity in older adults through mediating factors like sleep duration and pain. The paper addresses the decline of intrinsic capacity, which is crucial for healthy aging, and explores pathways that could inform interventions to improve longevity.

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