The changing immune landscape of innate-like T cells and other innate cells throughout life.

Marziyeh Taheri, Christopher Menne, Jeremy Anderson, Louis Perriman, Shuo Li, Stuart P Berzins, Paul V Licciardi, Thomas M Ashhurst, Sedigheh Jalali, Daniel G Pellicci

Murdoch Children's Research Institute, Melbourne, VIC, Australia. · pubmed

Paper

Abstract

Spectral flow cytometry is an advanced immunological tool that can enable comprehensive analysis of the immune system by simultaneously comparing innate and adaptive immune cells. Here, using a 40-color antibody panel, we advance our knowledge of innate-like cells by investigating chemokine receptors and maturation markers not usually assessed on these populations, examining age-related effects on these immune cell subsets. We characterize phenotypic changes of peripheral blood mononuclear cells (PBMCs) in three age groups: newborns (cord blood), adults aged 20-30 years, and adults aged > 70 years. We compare the age-related changes of innate cells, including ILCs, NK cells, monocytes, dendritic cells, and innate-like T cells, comparing them with memory T cells. We also examine subsets of CD4

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Research summary

The paper investigates age-related changes in innate-like T cells and other immune cell subsets. This research is relevant as it explores the immune landscape across different life stages, which can contribute to understanding the biological mechanisms of aging and potential interventions for age-related immune decline.

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