SIRT3 deficiency exacerbates cognitive decline by disrupting mitochondrial antioxidant homeostasis in D-galactose-induced aging mice.

Xiaobin An, Chenhong Li, Lu Zeng, Chao Wang, Siyu Huang, Tingting Li, Xing Luo, Yiyuan Guo, Hang Yu

Department of Pharmacy at The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.Department of Pharmacy at The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China. · pubmed

Paper

Abstract

Age-related cognitive decline poses a growing clinical burden, with mitochondrial oxidative stress recognized as a key mediator. Sirtuin 3 (SIRT3), a mitochondrial deacetylase, is a potential regulator of redox balance, but its role in hippocampal function and cognitive aging, particularly its translational potential, remains unclear.

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Research summary

SIRT3 deficiency exacerbates cognitive decline by disrupting mitochondrial antioxidant homeostasis in aging mice. The paper addresses the role of SIRT3 in mitochondrial function and cognitive aging, which are directly related to the mechanisms of aging and potential interventions for age-related cognitive decline.

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