The promise of organ rejuvenation to overcome the shortage in organ transplantation.

Mukhammad Kayumov, Zhuolun Song, Friederike Martin, Sarah Tsou, Yao Xiao, Hao Zhou, Stefan G Tullius

Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. · pubmed

Paper

Abstract

Organ shortage remains a major barrier in treating end-stage organ failure, with many patients dying while waiting or becoming medically unfit by the time an organ is offered. A substantial number of organs, particularly from older donors, remain unused due to concerns over age-related decline in quality. This review highlights emerging strategies to rejuvenate and optimize such organs by mitigating ischemia-reperfusion injury and reducing age-related immunogenicity. Advances in organ preservation, perfusion technologies, and novel therapies - including senotherapeutics, anti-inflammatory agents, and stem cell treatments - show promise in improving graft viability and bridging the gap between organ supply and demand.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that emerging strategies can rejuvenate older donor organs to improve graft viability. This is relevant as it addresses the aging-related decline in organ quality, aiming to mitigate the effects of aging on organ transplantation.

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