Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers.

Edyta Rychlicka-Buniowska, Daniil Sarkisyan, Monika Horbacz, Bożena Bruhn-Olszewska, Kinga Drężek-Chyła, Mikołaj Koszyński, Hanna Davies, Ulana Juhas, Magdalena Wójcik-Zalewska, Alicja Klich-Rączka, Lena Kilander, Martin Ingelsson, Karolina Bukowska-Strakova, Kazimierz Węglarczyk, Maciej Siedlar, Jarosław Baran, Janusz Ryś, Arkadiusz Piotrowski, Natalia Filipowicz, Jan P Dumanski

3P-Medicine Laboratory, Medical University of Gdańsk, Gdańsk, Poland [email protected] Laboratory, Medical University of Gdańsk, Gdańsk, Poland [email protected]. · pubmed

Paper

Abstract

Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events with implications for aging and Alzheimer disease (AD). LOY is linked to increased AD risk, whereas CHIP may be protective, and their co-occurrence remains unclear. We conducted whole-exome sequencing of CD4

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Research summary

The paper claims that the loss of the Y chromosome in Alzheimer's patients is associated with somatic mutations beyond known CHIP drivers. This research is relevant as it explores genetic factors that may contribute to aging and age-related diseases, potentially uncovering mechanisms that could inform future longevity studies.

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