Comprehensive transcriptomic profiling reveals lncRNA-miRNA-mRNA regulatory networks in skeletal muscle aging of mice.

Jinrui Jia, Qingyan Wang, Xuanye Jiang, Hao Chen, Minwei Huang, Bing Ni, Huiying Zhang, Xin'e Shi, Jianjun Jin

Laboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.Laboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. · pubmed

Paper

Abstract

As organisms age, physiological and pathological changes occur, with altered lncRNA expression playing a key role. However, their regulatory mechanisms in aging remain unclear. This study investigates the differential expression of lncRNAs between aged and young mice, and explores the lncRNA-miRNA-mRNA interplay to gain insights into the molecular basis of aging.

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Research summary

This study identifies differential lncRNA expression in aging skeletal muscle and explores the regulatory networks involved. The research addresses molecular mechanisms underlying aging, which is pertinent to understanding the root causes of aging and potential interventions.

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