Age-related change in skeletal muscle strength, size, and adiposity over 18 years in Caribbean men.

Lauren S Roe, Ryan K Cvejkus, Victor W Wheeler, Christopher L Gordon, Tanya S Kenkre, Joseph M Zmuda, Iva Miljkovic

Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, 130 N Bellefield Ave, Suite 300, Pittsburgh, PA, 15213, USA. [email protected]. · pubmed

Paper

Abstract

Declines in muscle strength outpace declines in muscle mass with age, so factors like muscle adiposity (i.e., myosteatosis) may contribute to strength loss. We describe intermuscular adipose tissue (IMAT) and grip strength over 18 years among middle-aged and older African Caribbean men. We hypothesized that increases in IMAT precede the loss of muscle area and strength, and that increased IMAT is independently associated with strength decline. Men (n = 339, 51.2 ± 5.5 years) were followed for 18.2 ± 0.9 years. Peripheral quantitative computed tomography at the calf determined IMAT (cm

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Research summary

Increased intermuscular adipose tissue is associated with declines in muscle strength over time. This study addresses age-related changes in muscle strength and adiposity, which are critical factors in understanding the biological mechanisms of aging and longevity.

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