miR-375-3p/STX6 Exacerbates Atherosclerosis by Promoting Endothelial Cell Senescence via Activation of TGF-Beta Signals.

Ying Zhu, Zhirui Liu, Yiqi Wan, Shuangjin Ding, Jiankun Liu, Andong Wu, Ximo Dai, Jin Zhou, Xueer Li, Xueting Gong, Man Liu, Xiao-Li Tian

Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Province Key Laboratory of Aging and Disease, Nanchang, Jiangxi, China.Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Province Key Laboratory of Aging and Disease, Nanchang, Jiangxi, China. · pubmed

Paper

Abstract

Atherosclerosis, a key pathological basis of cardio-cerebrovascular diseases, is closely associated with aging and endothelial cell senescence. The role of microRNAs (miRNAs) in regulating endothelial cell senescence and atherosclerosis remains incompletely understood. In this study, we discovered that miR-375-3p expression was significantly elevated in the serum of both aged and atherosclerotic mice. Overexpression of miR-375-3p induced endothelial cell senescence, evidenced by increased senescence-associated β-galactosidase (SA-β-gal) staining, upregulation of p15, IL6, and IL8, and inhibited cell colony formation. In vivo inhibition of miR-375-3p in ApoE

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Research summary

The paper claims that miR-375-3p exacerbates atherosclerosis by promoting endothelial cell senescence via TGF-Beta signaling. This research is relevant as it explores the mechanisms underlying endothelial cell senescence, which is a key factor in aging and age-related diseases like atherosclerosis.

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