Meningeal lymphatics as a therapeutic target for neurodegenerative disorders.

Yijia Feng, Shengya Wang, Huwei Xia, Xinyi Jiang, Mingming Wu, Sipei Pan, Weihong Song

Center for Geriatric Medicine, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The First Affiliated Hospital, Institute of Aging, Wenzhou Medical University, Wenzhou, 325027, China.Center for Geriatric Medicine, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The First Affiliated Hospital, Institute of Aging, Wenzhou Medical University, Wenzhou, 325027, China. · pubmed

Paper

Abstract

Advancements in visualization methods have brought the meningeal lymphatic system (MLS) into the spotlight. The meningeal lymphatic vessels (mLVs) play a vital role in draining cerebrospinal fluid and immune cells, acting as a central hub for immune surveillance in the brain. Age-related morphological and functional declines of mLVs suggest their involvement in the pathogenesis of neurodegenerative disorders (NDDs). In this article, we summarize key discoveries about the MLS over the past decade, highlight the neuro-immune crosstalk in the meninges, and discuss the role of mLVs in both brain homeostasis and neurodegeneration. As a critical regulator of brain function and a potential therapeutic target, the MLS offers a promising avenue for the diagnosis and treatment of NDDs, particularly Alzheimer's Disease.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that the meningeal lymphatic system (MLS) plays a critical role in brain homeostasis and neurodegeneration, suggesting it as a potential therapeutic target for neurodegenerative disorders. The focus on the MLS and its implications for neurodegenerative diseases aligns with understanding mechanisms that could influence aging and age-related pathologies.

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