Lymph node paracortex-inspired on-a-chip recapitulating immunosenescence: a cancer vaccine immunogenicity and antitumoral efficacy screening platform.

Surjendu Maity, Alireza Hassani Najafabadi, Satoru Kawakita, Danial Khorsandi, Can Yilgor, Christopher Jewell, Neda Mohaghegh, Mehmet Remzi Dokmeci, Ali Khademhosseini, Vadim Jucaud

Terasaki Institute for Biomedical Innovation, 21100 Erwin St, Woodland Hills, CA 91367, USA. [email protected] Institute for Biomedical Innovation, 21100 Erwin St, Woodland Hills, CA 91367, USA. [email protected]. · pubmed

Paper

Abstract

Immunosenescence dramatically reduces cancer vaccine efficacy in elderly patients, who represent the majority of cancer cases. Despite this clinical reality, the age-related immune decline is rarely considered in preclinical testing. Therefore, novel

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims to develop a platform that mimics immunosenescence to evaluate cancer vaccine efficacy in elderly patients. This research is relevant as it addresses the age-related decline in immune function, which is a significant factor in longevity and age-related diseases.

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