Hypoglycemic effects of lanostane triterpenoids from the fruiting bodies of Ganoderma lingzhi.

Jiaocen Guo, Li Yang, Mingli Han, Luting Dai, Qingyun Ma, Qingyi Xie, Haofu Dai, Yougen Wu, Youxing Zhao

Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. · pubmed

Paper

Abstract

The macrofungus Ganoderma is renown as a medicinal and edible mushroom in Asian countries for its potential to enhance vitality and promote longevity. Five previously undescribed lanostane triterpenoids, ganoderenic acids J-N (1-5), together with 42 known ones (6-47), were isolated from the fruiting bodies of Ganoderma lingzhi. The structures of the new compounds were elucidated through comprehensive spectroscopic analyses, NMR chemical shifts and electronic circular dichroism (ECD) calculations. Among them, compound 7 acted as a noncompetitive inhibitor against protein tyrosine phosphatase 1B (PTP1B) with IC

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Research summary

The paper claims that newly isolated lanostane triterpenoids from Ganoderma lingzhi exhibit hypoglycemic effects by inhibiting protein tyrosine phosphatase 1B (PTP1B). The research is relevant as it explores compounds that may influence metabolic pathways associated with aging and longevity.

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