Hydroxylation-Driven Microbial and Metabolic Reshaping: Coumarin Derivatives as Novel Prebiotics for Aging Gut Health.

Qile Zhang, Zhengming Zhou, Yiu Ming Cheung, Hoi Wa Yeung, Minghui Li, Chufeng He, Xiao Yu Tian, Cheng Li, Wing Tak Wong

School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR 999077, China.School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR 999077, China. · pubmed

Paper

Abstract

This study aimed to investigate the therapeutic potential of three naturally occurring coumarin derivatives─coumarin, umbelliferone, and esculetin, which exhibit distinct hydroxylation patterns in mitigating age-related gut dysbiosis through

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Research summary

The paper claims that coumarin derivatives can mitigate age-related gut dysbiosis through hydroxylation-driven microbial and metabolic reshaping. This research addresses gut health, which is increasingly recognized as a factor in aging and longevity, suggesting potential interventions for age-related dysbiosis.

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