Astragaloside IV and ceramide IIIB co-modified ferulic acid ethosomes: a promising novel approach for skin anti-aging.

Zhongrong Qin, Zhixin Wen, Hang Lu, Haoquan Yu, Yiyuan Liu, Jingmin Feng, Xiangyu Sun, Wei Lei, Ping Zhao

The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, China.The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, China. · pubmed

Paper

Abstract

Ferulic acid (FA) has multiple anti-aging functions but is limited by poor solubility, low bioavailability, and unclear mechanism in skincare. To overcome these challenges, we have developed ferulic acid ethosomes (FA-ES) co-modified with astragaloside IV and ceramide IIIB. Stability of FA-ES was confirmed through physicochemical characterization and molecular dynamics simulations. Comparative studies in zebrafish models showed FA-ES significantly reduced embryonic toxicity and β-galactosidase activity, improved skin hydration, repair capabilities, and antioxidant effects. In

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that co-modifying ferulic acid ethosomes with astragaloside IV and ceramide IIIB enhances their anti-aging properties. This research addresses the challenges of bioavailability and efficacy in anti-aging treatments, which are directly related to the mechanisms of aging.

Author of this paper? Send a correction.