Chaperone-mediated autophagy as a sex-specific modulator of synaptic proteostasis and neural function.

Rongcan Luo

Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, and Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China.Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, and Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China. · pubmed

Paper

Abstract

Chaperone-mediated autophagy (CMA), once considered a secondary or auxiliary degradation pathway, is now recognized as a central regulator of synaptic proteostasis. A recent study by Khawaja et al. (2025) in

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Research summary

Chaperone-mediated autophagy is identified as a key mechanism influencing synaptic proteostasis and neural function, with potential implications for aging-related cognitive decline. The focus on CMA as a modulator of synaptic health suggests a pathway that could address underlying mechanisms of aging and longevity.

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