Artesunate reverses BMSC senescence and ameliorates osteoporosis by upregulating NSD2.

Hui Jin, Yangyang Zhang, Chunying Hou, Weixin Chen, Fusen Wang, Hansheng Wang, Ao Gong, Zhaorui Xu, Jiabing Sun, Jilong Zou

Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. · pubmed

Paper

Abstract

Senile osteoporosis (SOP) is a typical ageing-related bone disease that is primarily prevalent in elderly people. The present study aimed to examine the therapeutic efficacy of artesunate (ART) administration in SOP and aged bone marrow stromal cells (BMSCs) and investigate its underlying mechanisms.

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Research summary

Artesunate administration reverses BMSC senescence and ameliorates osteoporosis in aged cells. The study addresses a mechanism related to cellular senescence, which is a key factor in aging and age-related diseases, making it relevant to longevity research.

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