Systems genetics of lifespan and senescence in Drosophila melanogaster.

Maryam Nasiri Aghdam, Desireé Unselt, Maria E Adonay, Tatiana V Morozova, Mary Anna Carbone, Gunjan H Arya, Lavanya Turlapati, Vijay Shankar, Robert R H Anholt, Trudy F C Mackay

Institute for Human Genetics, Clemson University, Greenwood, SC, USA.Institute for Human Genetics, Clemson University, Greenwood, SC, USA. · pubmed

Paper

Abstract

As populations age, the number of people with age-related chronic diseases increases, causing significant social, economic and health problems. Natural variation in lifespan depends on multiple interacting genes and environmental exposures. Its short generation time and many resources make Drosophila melanogaster an advantageous model to uncover the genetic architecture that underlies variation in lifespan.

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Research summary

The paper investigates the genetic factors influencing lifespan and senescence in Drosophila melanogaster. This research is relevant as it aims to uncover the genetic architecture underlying lifespan variation, which is directly related to understanding the mechanisms of aging.

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