Biological aging and lifespan in men and women using a Mendelian randomization study.

C M Schooling, Shun Li, Zhu Liduzi Jiesisibieke

Graduate School of Public Health and Health Policy, The City University of New York, 55 West 125th St, New York, NY, 10027, USA. [email protected] School of Public Health and Health Policy, The City University of New York, 55 West 125th St, New York, NY, 10027, USA. [email protected]. · pubmed

Paper

Abstract

Identification of targets of intervention to promote lifespan is crucial given lifespan is an important measure of public health. Telomere length and epigenetic clocks are key biological markers of aging, whether they are targets of intervention in men or women is unclear. We examined their associations with sex-specific lifespan in a Mendelian randomization study.

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Research summary

The paper investigates the associations between biological markers of aging and lifespan in a sex-specific manner using Mendelian randomization. This research is relevant as it seeks to identify potential intervention targets that could promote lifespan, addressing the root causes of aging rather than merely treating age-related diseases.

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