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RESEARCH PAPER / 2025-12-05

The influence of type 2 diabetes and its metabolic correlates in middle-aged adults on cognition at mid and later life; A systematic review and meta-analysis.

Oisin C Joyce, Cliodhna McHugh, David Mocker, Fiona Wilson, Áine M Kelly

Department of Physiology, School of Medicine, Level 2, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.Department of Physiology, School of Medicine, Level 2, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. · pubmed

Abstract

While previous studies have examined the link between Type 2 Diabetes Mellitus (T2DM) and cognitive function in middle-aged adults, no review has explored the long-term effects on cognition of T2DM when diagnosed at midlife. This review aims to investigate any association between T2DM and its metabolic correlates during midlife and measures of cognitive function, spanning from midlife into later life.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that Type 2 Diabetes Mellitus diagnosed at midlife is associated with cognitive decline in later life. This research is relevant as it explores the long-term effects of a metabolic condition on cognitive function, which is a significant aspect of aging and age-related diseases.

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