Telomere dynamics are influenced by sleep, sleep variability and circadian rhythms in older adults with or without alzheimer's risk.

Asrar Lehodey, Blandine Montagne, Stéphane Rehel, Perla Kaliman, Anne Chocat, Florence Mezenge, Brigitte Landeau, Vincent de la Sayette, Gaël Chételat, Géraldine Rauchs, Géraldine Poisnel

Normandie Univ, UNICAEN, INSERM U1237, Neuropresage Team, GIP Cyceron Boulevard Henri Becquerel, BP 5229, Caen Cedex 5, 14074, France. · pubmed

Paper

Abstract

Sleep and circadian rhythm disturbances have been related to cognitive decline and increased risk of Alzheimer's disease (AD). These disruptions are also closely associated with biological ageing processes. Telomere shortening, a key marker of cellular ageing, has been implicated in various age-related diseases, including AD. Although sleep disturbances have been linked to shorter telomere length (TL), the effects of sleep, its variability, and circadian rhythms on telomere dynamics (over 18 months) remain unknown. Furthermore, the interplay between these factors and AD risk has yet to be investigated in healthy older adults. Therefore, the objective of this study was to explore how sleep, sleep variability, and circadian rhythms affect telomere dynamics in healthy older adults and the influence of AD risk on these relationships.

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Research summary

The paper claims that sleep, sleep variability, and circadian rhythms influence telomere dynamics in older adults. This research is relevant as it explores the relationship between biological aging markers and lifestyle factors, potentially contributing to our understanding of aging processes and their implications for longevity.

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