Nrf2 modulates macrophage foam cells senescence and autophagy activation.

Kai Wen Wai, Yin Quan Tang, Jhi Biau Foo, Bey Hing Goh, Wei Hsum Yap

School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia. · pubmed

Paper

Abstract

Foam cell formation is a critical pathological process that contributes significantly to the development of atherosclerosis, influenced by processes such as vascular senescence and autophagy-lysosomal pathways. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has recently received interest due to its role in foam cell formation, but its connection to senescence and autophagy are still not well defined. This research investigated the role of Nrf2 in modulating senescence and autophagy in foam cells using an

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Research summary

Nrf2 modulates senescence and autophagy in macrophage foam cells. The study addresses mechanisms related to cellular senescence and autophagy, which are key processes in aging and age-related diseases, thus contributing to the understanding of longevity.

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