Gut microbiota preserves bone mass through modulating the hyodeoxycholic acid-TGR5 axis.

Xuan-Qi Zheng, Jie Huang, Wan-Qiong Yuan, Tong Wu, Huan Wang, Hao Liu, Yun-Di Zhang, Jin-Wen He, Chen Huang, Chun-Li Song

Department of Orthopaedics, Peking University Third Hospital, Beijing, China. · pubmed

Paper

Abstract

Osteoporosis is an age-related disease. The relationship between gut microbiota (GM) homeostasis and bone health is well established, but the mechanism of GM dysbiosis contributes to senile osteoporosis remains elusive. The objective of this study is to investigate the relationship between GM, bile acids (BAs) and their effects on bone mass.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that gut microbiota influences bone mass through the modulation of the hyodeoxycholic acid-TGR5 axis. This research is relevant as it explores the underlying mechanisms linking gut health to bone health, which could contribute to understanding and potentially mitigating age-related bone loss.

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