HIV infection and immunosenescence: challenges and intervention strategies.

Junyan Jin, Qianqian Xu, Xin Zhang, Aiwei Zhu, Wei Xia, Christiane Moog, Alex Siu Wing Chan, Tong Zhang, Bin Su

Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China. · pubmed

Paper

Abstract

Antiretroviral therapy has extended the life expectancy of people with HIV (PWH), leading to a rapidly expanding ageing population of PWH worldwide, including in low- and middle-income countries. The interaction between ageing and chronic HIV infection is closely associated with immunosenescence, and PWH are widely regarded as a model of accelerated immune ageing. Immunosenescence, characterized by a progressive decline in immune function and increased susceptibility to infections, contributes to a higher burden of age-related comorbidities and cancers, posing a major long-term health challenge for this population.

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Research summary

The paper discusses the challenges of immunosenescence in people with HIV and potential intervention strategies. It is relevant as it addresses the intersection of chronic disease and aging, focusing on the underlying mechanisms of immune aging in a specific population.

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