The unfolded protein response in progeria arteries originates from non-endothelial cell types.

Raquel A Silva, Fatih Sarigol, G Elif Karagöz, Selma Osmanagic-Myers, Roland Foisner

Max Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, Austria.Max Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, Austria. · pubmed

Paper

Abstract

Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease caused by a mutation in

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that the unfolded protein response in progeria arteries originates from non-endothelial cell types. This research addresses the underlying cellular mechanisms associated with Hutchinson-Gilford Progeria Syndrome, which is directly related to the biology of aging and could provide insights into the aging process and potential interventions.

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