Senescence Reprogramming Unleashes Tumor Immune Surveillance via Coordinated Gene Modulation.

Kai Zhao, Yu Yan, Bao-Ting Dong, Shan-Shan Pan, Xian-Zheng Zhang

Department of Chemistry, Department of Traditional Chinese Medicine of Zhongnan Hospital, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, 430072, P.R. China. · pubmed

Paper

Abstract

Cellular senescence can recruit immune cells for tumor therapy through the senescence-associated secretory phenotype (SASP). However, its therapeutic efficacy is limited by immune tolerance and the immunosuppressive tumor microenvironment (TME). Reprogramming tumor-specific senescence through coordinated modulation of P16

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Research summary

Reprogramming tumor-specific senescence enhances immune surveillance against tumors. This research addresses cellular senescence, which is a key aspect of aging and its associated decline in immune function, thus contributing to the understanding of aging mechanisms and potential interventions.

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