Cochlear endoplasmic reticulum stress causes connexin 26 degradation is involved in age-related hearing loss.

Xue Bai, Bing Liao, Wen-Hui Hu, Mei-Qun Wang, Yu Sun, Xu-Bo Chen, Kai Xu

Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, China. · pubmed

Paper

Abstract

Age-related hearing loss (ARHL) represents a progressive auditory disorder. Growing evidence indicates that degradation of connexin 26 (Cx26) in cochlear may constitute one of the pathogenic mechanisms in ARHL. However, the molecular mechanisms underlying age-related Cx26 degradation remain unclear. We systematically analyzed Cx26 expression patterns in C57BL/6J mice across different age groups and confirmed an age-dependent downregulation of Cx26 in the mouse cochlea. Notably, we observed concurrent upregulation of endoplasmic reticulum (ER) stress markers Glucose-regulated protein 78 (GRP78) and protein disulfide isomerase (PDI) in aged cochlear tissues. Furthermore,

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Research summary

The paper claims that cochlear endoplasmic reticulum stress leads to the degradation of connexin 26, contributing to age-related hearing loss. This research addresses a potential underlying mechanism of aging-related auditory decline, which is relevant to understanding and potentially mitigating age-related diseases.

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