Effect of Thrombopoietin Receptor Agonist Romiplostim on the Ionizing Radiation-Induced Premature Aging.

Masaru Yamaguchi, Tokuhisa Hirouchi, Yoshiaki Sato, Ikuo Kashiwakura

Department of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan.Department of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan. · pubmed

Paper

Abstract

Environmental stressors, such as ionizing radiation, accelerate aging by causing DNA damage and triggering pathways that lead to cell cycle arrest, apoptosis, and subsequent inflammation. The thrombopoietin receptor agonist romiplostim (RP), which is used as a clinical treatment for chronic idiopathic thrombocytopenic purpura and aplastic anemia, is known to be promising in reducing radiation-induced tissue damage. In this study, we established a mouse model of radiation-induced premature aging to evaluate the potential of RP in ameliorating this process. Female C57BL/6JJcl mice were subjected to total body irradiation with various irradiation schedules. Mice irradiated with 5 Gy every 4 weeks (total dose of 10 Gy over 2 months) showed a significant aging phenotype, including graying hair and elevated serum aging markers (CDKN2A/p16

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that the thrombopoietin receptor agonist romiplostim can ameliorate the aging phenotype induced by ionizing radiation. This research is relevant as it explores a potential intervention that addresses the mechanisms of aging, specifically the effects of environmental stressors on aging processes.

Author of this paper? Send a correction.