cGAS-STING signaling is blunted in senescent macrophages and monocytes in obesity.

Carine Raquel Richter Schmitz, Lucas Kich Grun, Bruno Kendi Makiyama, Luma Smidt Piazza, Alexandre Vontobel Padoin, Cláudio Cora Mottin, Moisés Evandro Bauer, Fátima Theresinha Costa Rodrigues Guma, Florencia María Barbé-Tuana

Graduate Program in Biological Sciences: Biochemistry, Federal University at Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Group of Inflammation and Cellular Senescence, Immunobiology Laboratory, School of Health Sciences and Life, Pontifical Catholic University at Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. · pubmed

Paper

Abstract

The cGAS-STING pathway is essential for immunity, detecting cytosolic DNA to trigger defense mechanisms and sterile inflammation linked to aging, obesity, and chronic inflammatory diseases. This study examines cGAS-STING signaling in senescent monocyte-derived macrophages (MDMs) and monocytes within the context of obesity.

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Research summary

The study claims that cGAS-STING signaling is impaired in senescent macrophages and monocytes due to obesity. This research is relevant as it explores the underlying mechanisms of immune dysfunction in aging and obesity, which are critical factors in the aging process and age-related diseases.

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