Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy.

Rui Zhang, Lei Huang, Meng Jin, Haiyang Kou, Jie Ma, Weijie Zhang, Jianbing Ma

Department of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, No. 555 East Youyi Road, Xi'an, 710054, Shaanxi, China. · pubmed

Paper

Abstract

Osteoarthritis (OA) is a common chronic and degenerative disease, the pathophysiological features of which involve the whole joint. In recent years, adipose tissue-derived mesenchymal stem cells (ADSCs) have attracted much attention in the field of regenerative medicine. Nonetheless, with aging in vivo or exogenous stress in vitro, mesenchymal stem cells undergo cellular senescence, resulting in limited therapeutic efficacy. Curcumin is a natural polyphenolic compound that has antioxidative, anti-inflammatory and antiapoptotic properties. We aimed to investigate the function and molecular mechanisms of the effects of curcumin on ADSC senescence and to explore the therapeutic efficacy of curcumin-pretreated ADSCs in OA management.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Curcumin can control the senescence of adipose-derived mesenchymal stem cells to enhance joint homeostasis for osteoarthritis therapy. The paper addresses cellular senescence, a key aspect of aging, and explores a potential intervention that could improve regenerative capacity in age-related conditions.

Author of this paper? Send a correction.