Oviductus Ranae alleviates D-galactose-induced ovarian aging by inhibiting ferroptosis and regulating the GPX4/ACSL4 pathway.

Xiaomei Ling, Cong Xie, Ming Li, Jie Li, Shun Liu, Liyue Sun, Xinxin Zeng, Zhen Zhang, Xuhui Zhang, Lei Liang

Medical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, PR China.Medical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, PR China. · pubmed

Paper

Abstract

Ovarian dysfunction caused by aging restricts female reproductive capacity and causes age-related health problems. Ferroptosis is an important mode of cell death during accelerated aging. Oviductus Ranae (OR), a traditional Chinese medicine, has been used to treat ovarian age-related diseases in women. However, the mechanisms through which OR mitigates ovarian aging, especially ferroptosis regulation, remain unclear. This study investigated the pharmacological effects and mechanisms of OR for ovarian aging in rats.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Oviductus Ranae alleviates ovarian aging by inhibiting ferroptosis through the GPX4/ACSL4 pathway. The study addresses a potential mechanism for mitigating ovarian aging, which is directly related to the biological processes of aging and longevity.

Author of this paper? Send a correction.