Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA.

Wei Chen, Jinjin Xu, Guodan Zeng, Rijing Ou, Changlin Yang, Chuang Xu, Yeqin Wang, Xinxin Wang, Qiuyan Li, Chenhui Zhao, Wenwen Zhou, Yu Lin, Wending Pang, Haiqiang Zhang, Jianhua Yin, Yan Zhang, Xin Jin

School of Medicine, South China University of Technology, Guangzhou, Guangdong, China. · pubmed

Paper

Abstract

Age and sex significantly impact DNA methylation patterns, however, existing datasets typically include only a subset of methylation sites in the human genome, hindering our thorough understanding.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims to identify age- and sex-associated DNA methylation signatures in human plasma cell-free DNA. This research is relevant as it explores the biological mechanisms of aging through DNA methylation, which could contribute to understanding the root causes of aging and potential interventions.

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