NAD+ restores proteostasis through splicing-dependent autophagy.

Ruixue Ai, Evandro F Fang

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Norway.Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Norway. · pubmed

Paper

Abstract

Autophagy preserves neuronal integrity by clearing damaged proteins and organelles, but its efficiency declines with aging and neurodegeneration. Depletion of the oxidized form of nicotinamide adenine dinucleotide (NAD

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Research summary

NAD+ supplementation enhances autophagy through splicing mechanisms to restore proteostasis in aging neurons. This research addresses the decline of autophagy efficiency with aging, which is a fundamental aspect of the aging process and its associated neurodegenerative diseases.

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