Space radiation induces distinct senescent phenotypes: Implications for space travel.

Louise E Pitcher, Bipasha Mukherjee, Ashley M Saathoff, Zachary A Eduvas, Josh Bartz, Xu Zhang, Nino Giorgadze, Tamar Pirtskhalava, Amyn A Habib, Nathan K LeBrasseur, Tamara Tchkonia, James L Kirkland, Xiao Dong, Sandeep Burma, Paul D Robbins

Masonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.Masonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. · pubmed

Paper

Abstract

As Earth's magnetic field weakens, space radiation begins to pose a significant threat to the health of not only space travelers, but the world's population. Space radiation, comprising high-energy and high-charge ions, creates distinct clusters of DNA damage and dense macromolecular damage that result in the accumulation of senescent cells (SnCs) known to play a critical role in promoting multimorbidity. Here, we demonstrate that human fibroblasts exposed to different forms of space radiation acquire senescence-associated phenotypes including morphological alterations and the accumulation of SA-ß-gal

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Research summary

Space radiation induces distinct senescent phenotypes in human fibroblasts. The study addresses the accumulation of senescent cells, which are implicated in aging and age-related diseases, thus contributing to the understanding of the root causes of aging in the context of space travel.

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