Development of a Dual-Cross-Linked Collagen-Based Bioink for High-Resolution 3D Bioprinting and Antiaging.

Caihong Fu, Yirui Fan, Jing Wang, Yi Yang, Guangyu Liu, Huixia He, Jianxi Xiao

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China. · pubmed

Paper

Abstract

The advancement of personalized antiaging therapies demands the convergence of biomaterial innovation and precision fabrication technologies. Here, we present the development of a dual-cross-linked collagen-based bioink, integrating methacrylated collagen (CMA) and 1,4-butanediol diglycidyl ether (BDDE), tailored for DLP-based bioprinting. BDDE functions as a chemical cross-linker by forming stable ether bonds with hydroxyl groups on the collagen backbone, thereby reinforcing the structural integrity of the matrix. Subsequent photo-cross-linking of CMA generates an interpenetrating network that imparts superior enhancements to mechanical resilience, proteolytic endurance, and structural robustness. Bioink supports high-resolution cell-laden printing and enables the fabrication of geometrically complex, high-fidelity constructs. Moreover, the incorporation of bioactive retinol (VA) allows for the fabrication of functionalized hydrogel facial patches with targeted antiaging activity.

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Research summary

The paper claims to develop a dual-cross-linked collagen-based bioink that supports high-resolution 3D bioprinting for antiaging applications. The relevance lies in its focus on creating biomaterials that could potentially address aspects of aging through innovative therapeutic applications.

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