Lower circadian rhythmicity of rest-activity patterns is associated with a higher risk of chronic kidney disease in older adults.
Abstract
As the global burden of chronic kidney disease (CKD) continues to rise, it is important to identify factors that may support preservation of kidney function with age. Circadian rhythmicity declines with age, and evidence suggests that circadian rhythms influence renal physiology, yet their role in long-term kidney health remains underexplored. We tested the hypothesis that lower circadian rhythmicity would be associated with an elevated risk of kidney function decline. About 1315 older adults participating in the Rush Memory and Aging Project, a prospective community-based cohort study of the chronic conditions of aging, were studied. The median age of participants was 81.5 years [IQR: 71.8-91.2], 76.3% were female, and 93.7% identified as Caucasian. The stability of the circadian activity rhythm was quantified from up to 10 consecutive days of wrist activity using interdaily stability (IS) metric. Lower baseline IS was associated with lower eGFR (estimate = -1.9 ml/min/1.73 m
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Research summary
Lower circadian rhythmicity is associated with a higher risk of chronic kidney disease in older adults. This paper is relevant as it explores the relationship between circadian rhythms and kidney health, which may provide insights into underlying mechanisms of aging and chronic disease progression.
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