Extracellular vesicles for delivery of functional telomerase.

Yingying He, Yumeng Cui, Lijuan Wang, Wen Yang, Ruping Wang, Yanghua Li, Yue Ma, Yanli Lin, Xiaojie Wu, Long Cheng, Chengjiang Zhou, Youliang Wang

Baotou Medical College, Baotou, 014040, China.Baotou Medical College, Baotou, 014040, China. · pubmed

Paper

Abstract

Telomerase, essential for maintaining chromosomal telomere integrity and preventing cellular senescence, represents a promising therapeutic target. However, the inherent risks associated with existing treatments for telomerase deficiency-related diseases necessitate the development of safe and precise targeted delivery systems capable of reaching specific cell populations. Extracellular vesicles (EVs), nanoscale membrane-bound particles naturally secreted by cells, mediate intercellular communication by transporting bioactive molecules, including proteins and nucleic acids. We hypothesized that EVs could function as intrinsic vehicles for telomerase delivery.

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Research summary

The paper claims that extracellular vesicles can be used as vehicles for delivering functional telomerase. This research is relevant as it addresses a potential therapeutic approach to maintain telomere integrity, which is directly linked to cellular aging and senescence, thus targeting a root cause of aging.

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