Quansanqi (derived from Panax notoginseng (Burk.) F. H. Chen) tablets extend the lifespan and ameliorate cellular inflammaging via regulating CD38 and senescence-associated secretory phenotype.

Yan Guo, Hong Yan, Chengzhi Zhong, Lvdong Gong, Weifeng Yang, Zhida Zi, Ting Li, Yi Xu, Desong Wu, Shanshan Wei, Tao Cui, Zhengwei Xie, Zhaoyun Zhu

Peking University-Yunnan Baiyao International Medical Research Center, Peking University Health Science Center, Beijing, 100191, China; Yunnan Institute of Materia Medica, Kunming, 650111, China; Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation, Kunming, 650111, China. · pubmed

Paper

Abstract

Quansanqi (PSQ) is derived from the whole plant of Panax notoginseng, including the flowers, stems, leaves, and roots. Its principal active ingredients include saponins, flavonoids, and polysaccharides. Unlike traditional P. notoginseng preparations, PSQ features a more diverse chemical composition. Aging is marked by systemic chronic inflammation, termed "inflamm-aging". Notably, PSQ exhibits significant anti-inflammatory properties. However, its anti-aging mechanism is unelucidated.

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Research summary

Quansanqi tablets extend lifespan and reduce cellular inflammaging by regulating CD38 and the senescence-associated secretory phenotype. The paper addresses the root causes of aging by exploring the anti-inflammatory properties of Quansanqi, which may contribute to lifespan extension and amelioration of age-related cellular processes.

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