Senescence in Aging and Alzheimer's Disease.

Li Sun, Chu Chen

Department of Cellular and Integrative Physiology, Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229, USA. · pubmed

Paper

Abstract

Cellular senescence, once considered a protective mechanism against oncogenesis, is now recognized as a key driver of aging and age-related diseases, including Alzheimer's disease (AD). In the central nervous system (CNS), senescence-like states emerge in both proliferative and post-mitotic cells-astrocytes, microglia, oligodendrocyte lineage cells, endothelial cells, pericytes, and even neurons-contributing to chronic dysfunction. Canonical pathways, such as p16

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Research summary

Cellular senescence contributes to chronic dysfunction in the central nervous system, impacting aging and Alzheimer's disease. The paper addresses the role of senescence in age-related diseases, which is pertinent to understanding the mechanisms of aging.

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