Single-Cell Atlas of Aging Human Skin Reveals FOSB-Related Transcriptional Programs and Druggable Targets.

Youcheng Zhang, Yimin Wang, Dongze Lyu, Yinv Gong, Renpeng Zhou

Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. · pubmed

Paper

Abstract

While human skin aging involves complex transcriptional alterations, the cell-type-specific regulatory mechanisms and therapeutic targets remain incompletely defined. The study aims to investigate aging-associated transcriptional programs and drug-responsive signatures at single-cell resolution.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The study identifies FOSB-related transcriptional programs in aging human skin and potential druggable targets. This research addresses the underlying transcriptional changes associated with aging, contributing to the understanding of aging mechanisms and potential interventions.

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