Iron Deficiency Impairs Muscle Stem Cell Proliferation and Skeletal Muscle Regeneration via HIF-2α Stabilization.

Wenyan Fu, Yang Liu, Amelia Yin, Liwei Xie, Hang Yin

Center for Molecular Medicine, The University of Georgia, Athens, Georgia, USA. · pubmed

Abstract

Functional iron deficiency affects a large proportion of patients with chronic diseases and is increasingly observed in older adults. Clinical evidence links iron deficiency to sarcopenia, yet the mechanistic relationship between iron status and muscle regeneration remains poorly defined. This study investigates how iron depletion alters muscle stem cell (MuSC) proliferation and skeletal muscle regeneration, focusing on HIF-2α signalling.

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Research summary

Iron deficiency impairs muscle stem cell proliferation and skeletal muscle regeneration through HIF-2α stabilization. This study addresses a mechanistic link between iron status and muscle regeneration, which is crucial for understanding and potentially mitigating age-related muscle decline.

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